Serrapeptase is an enzyme naturally produced by friendly serratia bacteria living in the intestines of silkworms. Living organisms produce enzymes to help speed up specific chemical processes. In the case of Serrapeptase, it helps speed up the break down of proteins, making it a proteolytic enzyme (50).
Serrapeptase production is absolutely essential for the survival of the silkworm. Once the silkworm has spun its cocoon and completed its transformation into a moth, it would be trapped inside the strong silk threads and die if it weren't for Serrapeptase. Because of the powerful protein-dissolving properties of Serrapeptase, this enzyme literally dissolves the protein molecules that make up the silk cocoon, allowing the moth to escape.
Amazingly, because enzymes are extremely specific, Serrapeptase only dissolves non-living proteins like those found in the cocoon, not the living tissue that makes up the newly transformed moth.
Although the role of Serrapeptase in nature is to literally eat through silkworm cocoons, researchers have found that it performs several additional functions that are beneficial to the human body. When taken orally on an empty stomach, Serrapeptase is absorbed by the small intestine and enters the bloodstream (19).
Once released into the body, this enzyme promotes the degradation of cellular debris that trigger inflammation by over-stimulating the immune system and causes fluid accumulations to become thinner, thereby facilitating the drainage of harmful substances away from the site of inflammation.
As a result, Serrapeptase has the ability to rapidly decrease the signs and symptoms of inflammation while speeding up tissue repair (20-25). It also digests proteins that form scar tissue, blood clots, cysts, mucus and arterial plaques, among others (13). Since living tissue is not broken down by Serrapeptase, taking this enzyme poses no threat to healthy tissue or cells.
Serrapeptase Reduces Pain and Inflammation?
Serrapeptase has the ability to improve both pain and inflammation. More specifically, when an injury occurs, proteins which are carried in the bloodstream (e.g., C3 and C4) often accumulate at the injury site. These types of proteins attack and kill harmful particles such as bacteria that may have entered the injury site. However, this influx of fluid increases swelling and inflammation. Serrapeptase leads to the reduction of these proteins at the injury site by thinning the fluid that has accumulated. This allows the proteins to attack and degrade harmful substances away from the site of inflammation. Serrapeptase itself also has the ability to breakdown dead proteins that have accumulated within bodily fluid. Therefore, this process leads to the reduction of swelling and inflammation while allowing harmful material to be removed from the body.
The ability of Serrapeptase to reduce excess fluid that may accumulate at the site of a wound (edema) also affords this enzyme with anti-edemic activity (13). It is not surprising that the use of enzymes with anti-inflammatory, proteolytic, fibrinolytic, and anti-edemic activity such as Serrapeptase, have become increasingly popular dietary supplements for individuals suffering from inflammation as well as swelling of the mucosal membranes (e.g., ear, nose, throat) (1).
Serrapeptase also has the ability to inhibit the release of pain-inducing amines such as Bradykinin from inflamed tissue (20,11, 26, 27). Bradykinin is a protein that causes blood vessels to dilate and its main function is to increase the sensation of pain. Bradykinin also makes nerves in inflamed tissue more sensitive, causing them to be hypersensitive to heat and light touch and creates a general sensation of soreness. By leading to the reduction of proteins that cause pain sensations and soreness, Serrapeptase shows promise as a pain-reducing supplement.
Due to these benefits, Serrapeptase also offers a safer alternative to long-term use of non-steroidal anti-inflammatory (NSAIDs) drugs (9, 10, 11, 15).
Serrapeptase Breaks Down Fibrin
Serrapeptase reduces the accumulation of fibrin in the body which subsequently decreases the risk of developing blood clots and arterial plaque. Fibrin is a protein that is typically produced by the body in response to an injury and is responsible for the formation of blood clots and scar tissue. When produced in the right amounts, fibrin prevents excessive bleeding from a wound and is an important part of the healing process. However, when too much is produced, blood clots may persist and increase in number, resulting in deadly health problems such as heart attacks, strokes, and deep vein thrombosis (DVT) (13, 28-30). Complications that are caused by fibrin can also lead to a number of chronic and progressive diseases such as Alzheimer's, endometriosis, and fibrocystic breast disease (FBD).
Fortunately, research has shown that taking enzymes that dissolve fibrin, which is the case for Serrapeptase, helps remove excess fibrin from the body and prevents this protein from being overproduced (10). Therefore, Serrapeptase has the potential health benefits of preventing dangerous blood clots from forming, reducing scarring, and improving cardiovascular health by preventing arterial plaque build-up.
Serrapeptase is also capable of reducing neutrophils in the bloodstream, which are white blood cells that have been associated with respiratory inflammation. Neutrophils generally accumulate at a site of infection to ingest and destroy harmful cells. However, they tend to accumulate in lungs of individuals who have respiratory diseases and cause inflammation (31). Serrapeptase may have beneficial effects on respiratory health by reducing the number of neutrophils that can accumulate in the respiratory system (15).
Serrapeptase Thins Fluids and Reduces Swelling?
Serrapeptase has been shown to thin the fluids produced in response to an injury and help drain this fluid away from the injured tissue. As a result, swelling decreases and tissue repair speeds up. This is the reason why Serrapeptase is often taken for athletic injuries and to prevent swelling after surgery (51). Serrapeptase also thins other secretions like mucus, making it a useful supplement for respiratory health.